Structure of calmodulin-KAR-2 complex 1 THE STRUCTURE OF CALMODULIN’S COMPLEX WITH KAR-2: A NOVEL MODE OF BINDING EXPLAINS THE DRUG’S UNIQUE PHARMACOLOGY

István Horváth, Veronika Harmat, András Perczel, Villő Pálfi, László Nyitray, Attila Nagy, Emma Hlavanda, Gábor Náray-Szabó, Judit Ovádi Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Karolina út 29 Budapest, H-1113 Hungary, Protein Modeling Group, Hungarian Academy of Sciences, Eötvös Loránd University, Pázmány sétány 1A., Budapest, H-1117 Hungary Department of Organic Chemistry, Eötvös Loránd University, Pázmány sétány 1A., Budapest, H-1117 Hungary, Department of Biochemistry, Eötvös Loránd University, Pázmány sétány 1A., Budapest H-1117 Hungary, Depatment of Theoretical Chemistry, Eötvös Loránd University, Pázmány sétány 1A., Budapest H1117 Hungary, These two authors contributed equally to this work. Corresponding author: Prof. Judit Ovádi, Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Karolina út 29., Budapest, H-1113 Hungary Phone: (+36-1) 279-3129 Fax: (+36-1) 466-5465 E-mail: [email protected] JBC Papers in Press. Published on December 13, 2004 as Manuscript M410353200